IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies.
Identifieur interne : 000155 ( Main/Exploration ); précédent : 000154; suivant : 000156IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies.
Auteurs : RBID : pubmed:24291267Abstract
We demonstrate a biosensor structure consisting of an IGZO (Indium-Gallium-Zinc-Oxide) TFT (thin film transistor) and an extended sensing pad. The TFT acts as the sensing and readout device, while the sensing pad ensures the isolation of biological solution from the transistor channel layer, and meanwhile increases the sensing area. The biosensor is functionalized by first applying ZnO nanorods to increase the surface area for attracting electrical charges of EGFR (epidermal growth factor receptor) antibodies. The device is able to selectively detect 36.2 fM of EGFR in the total protein solution of 0.1 ng/ml extracted from squamous cell carcinoma (SCC). Furthermore, the conjugation duration of the functionalized device with EGFR can be limited to 3 min, implying that the biosensor has the advantage for real-time detection.
DOI: 10.1016/j.bios.2013.10.043
PubMed: 24291267
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies.</title><author><name sortKey="Shen, Yi Chun" uniqKey="Shen Y">Yi-Chun Shen</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.</nlm:affiliation><country xml:lang="fr">République de Chine (Taïwan)</country><wicri:regionArea>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Chun Hsu" uniqKey="Yang C">Chun-Hsu Yang</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.</nlm:affiliation><country xml:lang="fr">République de Chine (Taïwan)</country><wicri:regionArea>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Shu Wen" uniqKey="Chen S">Shu-Wen Chen</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.</nlm:affiliation><country xml:lang="fr">République de Chine (Taïwan)</country><wicri:regionArea>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Shou Hao" uniqKey="Wu S">Shou-Hao Wu</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.</nlm:affiliation><country xml:lang="fr">République de Chine (Taïwan)</country><wicri:regionArea>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Tsung Lin" uniqKey="Yang T">Tsung-Lin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan. Electronic address: tlyang@ntu.edu.tw.</nlm:affiliation><country xml:lang="fr">République de Chine (Taïwan)</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Jian Jang" uniqKey="Huang J">Jian-Jang Huang</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan; Department of Electrical Engineering, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan. Electronic address: jjhuang@cc.ee.ntu.edu.tw.</nlm:affiliation><country xml:lang="fr">République de Chine (Taïwan)</country><wicri:regionArea>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan; Department of Electrical Engineering, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><date when="2014">2014</date><idno type="RBID">pubmed:24291267</idno><idno type="pmid">24291267</idno><idno type="doi">10.1016/j.bios.2013.10.043</idno><idno type="wicri:Area/Main/Corpus">000267</idno><idno type="wicri:Area/Main/Curation">000267</idno><idno type="wicri:Area/Main/Exploration">000155</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We demonstrate a biosensor structure consisting of an IGZO (Indium-Gallium-Zinc-Oxide) TFT (thin film transistor) and an extended sensing pad. The TFT acts as the sensing and readout device, while the sensing pad ensures the isolation of biological solution from the transistor channel layer, and meanwhile increases the sensing area. The biosensor is functionalized by first applying ZnO nanorods to increase the surface area for attracting electrical charges of EGFR (epidermal growth factor receptor) antibodies. The device is able to selectively detect 36.2 fM of EGFR in the total protein solution of 0.1 ng/ml extracted from squamous cell carcinoma (SCC). Furthermore, the conjugation duration of the functionalized device with EGFR can be limited to 3 min, implying that the biosensor has the advantage for real-time detection.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">24291267</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>14</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-4235</ISSN><JournalIssue CitedMedium="Internet"><Volume>54</Volume><PubDate><Year>2014</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Biosensors & bioelectronics</Title><ISOAbbreviation>Biosens Bioelectron</ISOAbbreviation></Journal><ArticleTitle>IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies.</ArticleTitle><Pagination><MedlinePgn>306-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bios.2013.10.043</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0956-5663(13)00745-8</ELocationID><Abstract><AbstractText>We demonstrate a biosensor structure consisting of an IGZO (Indium-Gallium-Zinc-Oxide) TFT (thin film transistor) and an extended sensing pad. The TFT acts as the sensing and readout device, while the sensing pad ensures the isolation of biological solution from the transistor channel layer, and meanwhile increases the sensing area. The biosensor is functionalized by first applying ZnO nanorods to increase the surface area for attracting electrical charges of EGFR (epidermal growth factor receptor) antibodies. The device is able to selectively detect 36.2 fM of EGFR in the total protein solution of 0.1 ng/ml extracted from squamous cell carcinoma (SCC). Furthermore, the conjugation duration of the functionalized device with EGFR can be limited to 3 min, implying that the biosensor has the advantage for real-time detection.</AbstractText><CopyrightInformation>© 2013 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Yi-Chun</ForeName><Initials>YC</Initials><Affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.</Affiliation></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Chun-Hsu</ForeName><Initials>CH</Initials><Affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.</Affiliation></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Shu-Wen</ForeName><Initials>SW</Initials><Affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.</Affiliation></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Shou-Hao</ForeName><Initials>SH</Initials><Affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan.</Affiliation></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Tsung-Lin</ForeName><Initials>TL</Initials><Affiliation>Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan. Electronic address: tlyang@ntu.edu.tw.</Affiliation></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Jian-Jang</ForeName><Initials>JJ</Initials><Affiliation>Graduate Institute of Photonics and Optoelectronics, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan; Department of Electrical Engineering, National Taiwan University, 1, Roosevelt Road, Section 4, Taipei 106, Taiwan. Electronic address: jjhuang@cc.ee.ntu.edu.tw.</Affiliation></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>11</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biosens Bioelectron</MedlineTA><NlmUniqueID>9001289</NlmUniqueID><ISSNLinking>0956-5663</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Biosensors</Keyword><Keyword MajorTopicYN="N">Nanorods</Keyword><Keyword MajorTopicYN="N">Thin film transistors</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>8</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>10</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>10</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>11</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24291267</ArticleId><ArticleId IdType="pii">S0956-5663(13)00745-8</ArticleId><ArticleId IdType="doi">10.1016/j.bios.2013.10.043</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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